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- Title
The ouabain-binding site of the α2 isoform of Na,K-ATPase plays a role in blood pressure regulation during pregnancy.
- Authors
Oshiro, Naomi; Dostanic-Larson, Iva; Neumann, Jon C; Lingrel, Jerry B
- Abstract
The cardiotonic steroid/ouabain-binding site of the α subunit of Na,K-ATPase is thought to play an important role in cardiovascular homeostasis. Previously, we demonstrated the cardiotonic steroid-binding site of the α2 Na,K-ATPase is involved in adrenocorticotropic hormone (ACTH)-induced hypertension by using gene-modified α2(R/R) mice in which the cardiotonic steroid-binding site is relatively resistant to ouabain compared to the ouabain-sensitive wild-type α2(S/S) mice. To further explore the importance of this site in the cardiovascular system, we investigated blood pressure regulation during pregnancy in mice with the α2(R/R) isoform.
- Publication
American journal of hypertension, 2010, Vol 23, Issue 12, p1279
- ISSN
1941-7225
- Publication type
Journal Article
- DOI
10.1038/ajh.2010.195