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- Title
GOSR2 Lys67Arg is associated with hypertension in whites.
- Authors
Meyer, Tamra E; Shiffman, Dov; Morrison, Alanna C; Rowland, Charles M; Louie, Judy Z; Bare, Lance A; Ross, David A; Arellano, Andre R; Chasman, Daniel I; Ridker, Paul M; Pankow, James S; Coresh, Josef; Malloy, Mary J; Kane, John P; Ellis, Stephen G; Devlin, James J; Boerwinkle, Eric
- Abstract
Hypertension is a risk factor for coronary heart disease (CHD), but the causes of hypertension remain largely unknown. Genetic variation is thought to contribute to the etiology of hypertension. We tested a single-nucleotide polymorphism (SNP) (Lys67Arg, rs197922) in the Golgi SNAP Receptor Complex Member 2 (GOSR2) gene for association with hypertension and blood pressure (BP). We chose this SNP because it was nominally associated with CHD in earlier studies. Further, GOSR2 is located in a linkage region for hypertension and BP in human and animal studies.
- Publication
American journal of hypertension, 2009, Vol 22, Issue 2, p163
- ISSN
1941-7225
- Publication type
Journal Article
- DOI
10.1038/ajh.2008.336