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- Title
Performance of Lynch syndrome predictive models in a multi-center US referral population.
- Authors
Khan, Omar; Blanco, Amie; Conrad, Peggy; Gulden, Cassandra; Moss, Tovah Z; Olopade, Olufunmilayo I; Kupfer, Sonia S; Terdiman, Jonathan
- Abstract
Lynch syndrome is the most common cause of inherited colorectal cancer (CRC) and is due to germline mutations in mismatch repair (MMR) genes. Early Lynch syndrome diagnosis and appropriate CRC surveillance improves mortality. Traditional qualitative clinical criteria including Amsterdam and Bethesda guidelines may miss mutation carriers. Recently, quantitative predictive models including MMRPredict, PREMM(1,2,6), and MMRPro were developed to facilitate diagnosis. However, these models remain to be externally validated in the United States. Therefore, we evaluated the test characteristics of Lynch syndrome predictive models in a tertiary referral group at two US academic centers.
- Publication
The American journal of gastroenterology, 2011, Vol 106, Issue 10, p1822
- ISSN
1572-0241
- Publication type
Journal Article
- DOI
10.1038/ajg.2011.200