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- Title
Proton pump inhibitors and risk of fracture: a systematic review and meta-analysis of observational studies.
- Authors
Ngamruengphong, Saowanee; Leontiadis, Grigorios I; Radhi, Saba; Dentino, Andrew; Nugent, Kenneth
- Abstract
Proton pump inhibitors (PPIs) are widely used in several acid-related gastrointestinal disorders. In vivo studies have suggested that gastric suppression by PPIs could result in decreased intestinal calcium absorption. Subsequently, there have been concerns that the chronic use of a PPI is associated with an increased risk of bone fracture. However, the results of clinical studies are conflicting.
- Publication
The American journal of gastroenterology, 2011, Vol 106, Issue 7, p1209
- ISSN
1572-0241
- Publication type
Journal Article
- DOI
10.1038/ajg.2011.113