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- Title
Role of E-cadherin in the pathogenesis of gastroesophageal reflux disease.
- Authors
Jovov, Biljana; Que, Jianwen; Tobey, Nelia A; Djukic, Zorka; Hogan, Brigid L M; Orlando, Roy C
- Abstract
An early event in the pathogenesis of gastroesophageal reflux disease (GERD) is an acid-induced increase in junctional (paracellular) permeability in esophageal epithelium (EE). The molecular events that account for this change are unknown. E-cadherin is a junctional protein important in barrier function in EE. Therefore, defects in barrier function in EE were sought in GERD as well as whether their presence correlated with abnormalities in e-cadherin.
- Publication
The American journal of gastroenterology, 2011, Vol 106, Issue 6, p1039
- ISSN
1572-0241
- Publication type
Journal Article
- DOI
10.1038/ajg.2011.102