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- Title
Topical rosiglitazone treatment improves ulcerative colitis by restoring peroxisome proliferator-activated receptor-gamma activity.
- Authors
Pedersen, Gitte; Brynskov, Jørn
- Abstract
Impaired epithelial expression of peroxisome proliferator-activated receptor-gamma (PPARgamma) has been described in animal colitis models and briefly in patients with ulcerative colitis, but the functional significance in humans is not well defined. We examined PPARgamma expression and functional activity in human colonic epithelium and explored the potential of topical treatment with rosiglitazone (a PPARgamma ligand) in patients with ulcerative colitis.
- Publication
The American journal of gastroenterology, 2010, Vol 105, Issue 7, p1595
- ISSN
1572-0241
- Publication type
Journal Article
- DOI
10.1038/ajg.2009.749