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- Title
NCX-1000, a nitric oxide-releasing derivative of UDCA, does not decrease portal pressure in patients with cirrhosis: results of a randomized, double-blind, dose-escalating study.
- Authors
Berzigotti, Annalisa; Bellot, Pau; De Gottardi, Andrea; Garcia-Pagan, Juan Carlos; Gagnon, Caroline; Spénard, Jean; Bosch, Jaime
- Abstract
NCX-1000 (2(acetyloxy) benzoic acid-3(nitrooxymethyl)phenyl ester) is an nitric oxide (NO)-releasing derivative of ursodeoxycholic acid (UDCA), which showed selective vasodilatory effect on intrahepatic circulation in animal models of cirrhosis. This study was aimed at testing the efficacy and tolerability of this compound in patients with cirrhosis and portal hypertension.
- Publication
The American journal of gastroenterology, 2010, Vol 105, Issue 5, p1094
- ISSN
1572-0241
- Publication type
Journal Article
- DOI
10.1038/ajg.2009.661