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- Title
Combined polymorphisms in genes encoding the inflammasome components NALP3 and CARD8 confer susceptibility to Crohn's disease in Swedish men.
- Authors
Schoultz, Ida; Verma, Deepti; Halfvarsson, Jonas; Törkvist, Leif; Fredrikson, Mats; Sjöqvist, Urban; Lördal, Mikael; Tysk, Curt; Lerm, Maria; Söderkvist, Peter; Söderholm, Johan D
- Abstract
Crohn's disease (CD) is characterized by overproduction of proinflammatory cytokines like interleukin (IL)-1beta. Production of mature IL-1beta is dependent on a caspase-1-activating protein complex called the NALP3 inflammasome, composed of NALP3, ASC, and CARD8. NALP3 shares structural similarities with Nod2, and both of these proteins are required for bacteria-induced IL-1beta secretion. The combination of the polymorphisms CARD8 (C10X)and NALP3 (Q705K) was recently shown to be associated with rheumatoid arthritis.Our aim was to investigate whether these combined polymorphisms play a role in the susceptibility to CD.
- Publication
The American journal of gastroenterology, 2009, Vol 104, Issue 5, p1180
- ISSN
1572-0241
- Publication type
Journal Article
- DOI
10.1038/ajg.2009.29