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- Title
A shorter duration of pre-transplant abstinence predicts problem drinking after liver transplantation.
- Authors
Tandon, Puneeta; Goodman, Karen J; Ma, Mang M; Wong, Winnie W; Mason, Andrew L; Meeberg, Glenda; Bergsten, Donna; Carbonneau, Michelle; Bain, Vincent G
- Abstract
Liver transplantation for alcoholic liver disease (ALD) can be complicated by abusive or "problem" drinking (PD) after transplant. There are limited data for evaluating the effect of pre-transplant abstinence on post-transplant PD. Few existing studies have included a substantial number of patients with co-existing causes of hepatic dysfunction, and the effect of PD on survival in recent European studies has been controversial. We hypothesized that a longer duration of pre-transplant abstinence would lead to less PD after transplantation. Accordingly, the objectives of this study are to analyze a North American cohort of patients with ALD with or without a secondary diagnosis of liver disease to estimate (i) the incidence of PD and its predictors, as well as (ii) the effect of PD on patient survival.
- Publication
The American journal of gastroenterology, 2009, Vol 104, Issue 7, p1700
- ISSN
1572-0241
- Publication type
Journal Article
- DOI
10.1038/ajg.2009.226