We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Expression pattern and functional relevance of epidermal growth factor receptor and cyclooxygenase-2: novel chemotherapeutic targets in pancreatic endocrine tumors?
- Authors
Bergmann, Frank; Breinig, Marco; Höpfner, Michael; Rieker, Ralf J; Fischer, Lars; Köhler, Christian; Esposito, Irene; Kleeff, Jörg; Herpel, Esther; Ehemann, Volker; Friess, Helmut; Schirmacher, Peter; Kern, Michael A
- Abstract
Pancreatic endocrine tumors represent morphologically and biologically heterogeneous neoplasms. Well-differentiated endocrine tumors (benign or of uncertain behavior) can be distinguished from well-differentiated and poorly differentiated endocrine carcinomas. Although many well-differentiated endocrine carcinomas show rather low rates of tumor growth, more than two-thirds of pancreatic endocrine carcinomas display distant metastases at the time of diagnosis. As the currently applied therapies beyond surgery only achieve partial or complete response rates of approximately 15%, additional chemotherapeutic targets are needed, especially in the therapy of inoperable and progressive pancreatic endocrine carcinomas.
- Publication
The American journal of gastroenterology, 2009, Vol 104, Issue 1, p171
- ISSN
1572-0241
- Publication type
Journal Article
- DOI
10.1038/ajg.2008.33