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- Title
The temporal requirement for endothelin receptor-B signalling during neural crest development.
- Authors
Shin, M K; Levorse, J M; Ingram, R S; Tilghman, S M
- Abstract
Endothelin receptor B (EDNRB) is a G-protein-coupled receptor with seven transmembrane domains which is required for the development of melanocytes and enteric neurons. Mice that are homozygous for a null mutation in the Ednrb gene are almost completely white and die as juveniles from megacolon. To determine when EDNRB signalling is required during embryogenesis, we have exploited the tetracycline-inducible system to generate strains of mice in which the endogenous Ednrb locus is under the control of the tetracycline-dependant transactivators tTa or rtTA. By using this system to express Ednrb at different stages of embryogenesis, we have determined that EDNRB is required during a restricted period of neural crest development between embryonic days 10 and 12.5. Moreover, our results imply that EDNRB is required for the migration of both melanoblasts and enteric neuroblasts.
- Publication
Nature, 1999, Vol 402, Issue 6761, p496
- ISSN
0028-0836
- Publication type
Journal Article
- DOI
10.1038/990040