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- Title
CRMP-2 induces axons in cultured hippocampal neurons.
- Authors
Inagaki, N; Chihara, K; Arimura, N; Ménager, C; Kawano, Y; Matsuo, N; Nishimura, T; Amano, M; Kaibuchi, K
- Abstract
In cultured hippocampal neurons, one axon and several dendrites differentiate from a common immature process. Here we found that CRMP-2/TOAD-64/Ulip2/DRP-2 (refs. 2-4) level was higher in growing axons of cultured hippocampal neurons, that overexpression of CRMP-2 in the cells led to the formation of supernumerary axons and that expression of truncated CRMP-2 mutants suppressed the formation of primary axon in a dominant-negative manner. Thus, CRMP-2 seems to be critical in axon induction in hippocampal neurons, thereby establishing and maintaining neuronal polarity.
- Publication
Nature neuroscience, 2001, Vol 4, Issue 8, p781
- ISSN
1097-6256
- Publication type
Journal Article
- DOI
10.1038/90476