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- Title
Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia.
- Authors
Ma, Z; Morris, S W; Valentine, V; Li, M; Herbrick, J A; Cui, X; Bouman, D; Li, Y; Mehta, P K; Nizetic, D; Kaneko, Y; Chan, G C; Chan, L C; Squire, J; Scherer, S W; Hitzler, J K
- Abstract
t(1;22) is the principal translocation of acute megakaryoblastic leukemias. Here we show this chromosomal rearrangement to result in the fusion of two novel genes, RNA-binding motif protein-15 (RBM15), an RNA recognition motif-encoding gene with homology to Drosophila spen, and Megakaryoblastic Leukemia-1 (MKL1), a gene encoding an SAP (SAF-A/B, Acinus and PIAS) DNA-binding domain.
- Publication
Nature genetics, 2001, Vol 28, Issue 3, p220
- ISSN
1061-4036
- Publication type
Journal Article
- DOI
10.1038/90054