We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses.
- Authors
Gonzalo, J A; Tian, J; Delaney, T; Corcoran, J; Rottman, J B; Lora, J; Al-garawi, A; Kroczek, R; Gutierrez-Ramos, J C; Coyle, A J
- Abstract
We examined the requirement for and cooperation between CD28 and inducible costimulator (ICOS) in effective T helper (TH) cell responses in vivo. We found that both CD28 and ICOS were critical in determining the outcome of an immune response; cytolytic T lymphocyte-associated antigen 4-immunoglobulin (CTLA-4-Ig), ICOS-Ig and/or a neutralizing ICOS monoclonal antibody attenuated T cell expansion, TH2 cytokine production and eosinophilic inflammation. CD28-dependent signaling was essential during priming, whereas ICOS-B7RP-1 regulated TH effector responses, and the up-regulation of chemokine receptors that determine T cell migration. Our data suggests a scenario whereby both molecules regulate the outcome of the immune response but play separate key roles: CD28 primes T cells and ICOS regulates effector responses.
- Publication
Nature immunology, 2001, Vol 2, Issue 7, p597
- ISSN
1529-2908
- Publication type
Journal Article
- DOI
10.1038/89739