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- Title
Solution structure of the PX domain, a target of the SH3 domain.
- Authors
Hiroaki, H; Ago, T; Ito, T; Sumimoto, H; Kohda, D
- Abstract
The phox homology (PX) domain is a novel protein module containing a conserved proline-rich motif. We have shown that the PX domain isolated from the human p47phox protein, a soluble subunit of phagocyte NADPH oxidase, binds specifically to the C-terminal SH3 domain derived from the same protein. The solution structure of p47 PX has an alpha + beta structure with a novel folding motif topology and reveals that the proline-rich motif is presented on the molecular surface for easy recognition by the SH3 domain. The proline-rich motif of p47 PX in the free state adopts a distorted left-handed polyproline type II helix conformation.
- Publication
Nature structural biology, 2001, Vol 8, Issue 6, p526
- ISSN
1072-8368
- Publication type
Journal Article
- DOI
10.1038/88591