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- Title
Immunological adjuvants promote activated T cell survival via induction of Bcl-3.
- Authors
Mitchell, T C; Hildeman, D; Kedl, R M; Teague, T K; Schaefer, B C; White, J; Zhu, Y; Kappler, J; Marrack, P
- Abstract
Injection of soluble protein antigen into animals causes abortive proliferation of the responding T cells. Immunological adjuvants boost T cell responses at least in part by increasing the survival of activated T cells during and after the initial proliferative phase of their clonal expansion. To understand how adjuvants promote T cell survival, we used gene microarrays to analyze gene expression in T cells activated either with antigen alone or in the presence of two different adjuvants. Among the genes whose expression was increased by both adjuvants was the IkappaB family member Bcl-3. Retroviral infection experiments showed that expression of Bcl-3 increased survival of activated T cells in vitro and in vivo. Adjuvants may therefore improve survival of activated T cells via induction of Bcl-3.
- Publication
Nature immunology, 2001, Vol 2, Issue 5, p397
- ISSN
1529-2908
- Publication type
Journal Article
- DOI
10.1038/87692