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- Title
A structural view of mitochondria-mediated apoptosis.
- Authors
Shi, Y
- Abstract
Mitochondria-mediated apoptosis plays a central role in animal development and tissue homeostasis, and its alteration results in a range of malignant disorders including cancer. Upon apoptotic stimuli, the mitochondrial proteins cytochrome c and Smac/DIABLO are released into the cytosol, where they synergistically activate caspases by activating Apaf-1 and relieving the apoptotic inhibition by IAPs. Recent biochemical and structural studies reveal a molecular basis for these important events and identify an evolutionarily conserved mechanism of apoptosis from fruit flies to mammals.
- Publication
Nature structural biology, 2001, Vol 8, Issue 5, p394
- ISSN
1072-8368
- Publication type
Journal Article
- DOI
10.1038/87548