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- Title
Thymic selection of CD4<sup>+</sup>CD25<sup>+</sup> regulatory T cells induced by an agonist self-peptide.
- Authors
Jordan, Martha S.; Boesteanu, Alina; Reed, Amy J.; Petrone, Andria L.; Holenbeck, Andrea E.; Lerman, Melissa A.; Naji, Ali; Caton, Andrew J.
- Abstract
Despite accumulating evidence that regulatory T cells play a crucial role in preventing autoimmunity, the processes underlying their generation during immune repertoire formation are unknown. We show here that interactions with a single self-peptide can induce thymocytes that bear an autoreactive T cell receptor (TCR) to undergo selection to become CD4+CD25+ regulatory T cells. Selection of CD4+CD25+ thymocytes appears to require a TCR with high affinity for a self peptide because thymocytes that bear TCRs with low affinity do not undergo selection into this pathway. Our findings indicate that specificity for self-peptides directs the selection of CD4+CD25+ regulatory thymocytes by a process that is distinct from positive selection and deletion.
- Publication
Nature Immunology, 2001, Vol 2, Issue 4, p301
- ISSN
1529-2908
- Publication type
Academic Journal
- DOI
10.1038/86302