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- Title
NF-kappaB is activated and promotes cell death in focal cerebral ischemia.
- Authors
Schneider, A; Martin-Villalba, A; Weih, F; Vogel, J; Wirth, T; Schwaninger, M
- Abstract
The transcription factor NF-kappaB is a regulator of cell death or survival. To investigate the role of NF-kappaB in neuronal cell death, we studied its activation in a rodent model of stroke. In the ischemic hemisphere, NF-kappaB was activated, as determined by increased expression of an NF-kappaB-driven reporter transgene, nuclear translocation of NF-kappaB in neurons and enhanced DNA binding of NF-kappaB subunits RelA and p50. In p50 knockout mice, ischemic damage was significantly reduced. This indicates a cell death-promoting role of NF-kappaB in focal ischemia. NF-kappaB may provide a new pharmacological target in neurologic disease.
- Publication
Nature medicine, 1999, Vol 5, Issue 5, p554
- ISSN
1078-8956
- Publication type
Journal Article
- DOI
10.1038/8432