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- Title
A biochemical function for attractin in agouti-induced pigmentation and obesity.
- Authors
He, L; Gunn, T M; Bouley, D M; Lu, X Y; Watson, S J; Schlossman, S F; Duke-Cohan, J S; Barsh, G S
- Abstract
Agouti protein, a paracrine signaling molecule normally limited to skin, is ectopically expressed in lethal yellow (A(y)) mice, and causes obesity by mimicking agouti-related protein (Agrp), found primarily in the hypothalamus. Mouse attractin (Atrn) is a widely expressed transmembrane protein whose loss of function in mahogany (Atrn(mg-3J)/ Atrn(mg-3J)) mutant mice blocks the pleiotropic effects of A(y). Here we demonstrate in transgenic, biochemical and genetic-interaction experiments that attractin is a low-affinity receptor for agouti protein, but not Agrp, in vitro and in vivo. Additional histopathologic abnormalities in Atrn(mg-3J)/Atrn(mg-3J) mice and cross-species genomic comparisons indicate that Atrn has multiple functions distinct from both a physiologic and an evolutionary perspective.
- Publication
Nature genetics, 2001, Vol 27, Issue 1, p40
- ISSN
1061-4036
- Publication type
Journal Article
- DOI
10.1038/83741