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- Title
Reciprocal regulation of polarized cytokine production by effector B and T cells.
- Authors
Harris, D P; Haynes, L; Sayles, P C; Duso, D K; Eaton, S M; Lepak, N M; Johnson, L L; Swain, S L; Lund, F E
- Abstract
Although B cells produce cytokines it is not known whether B cells can differentiate into effector subsets that secrete polarized arrays of cytokines. We have identified two populations of "effector" B cells (Be1 and Be2) that produce distinct patterns of cytokines depending on the cytokine environment in which the cells were stimulated during their primary encounter with antigen and T cells. These effector B cell subsets subsequently regulate the differentiation of naïve CD4+ T cells to TH1 and TH2 cells through production of polarizing cytokines such as interleukin 4 and interferon gamma. In addition, Be1 and Be2 cells could be identified in animals that were infected with pathogens that preferentially induce a Type 1 and Type 2 immune response. Together these results suggest that, in addition to their well defined role in antibody production, B cells may regulate immune responses to infectious pathogens through their production of cytokines.
- Publication
Nature immunology, 2000, Vol 1, Issue 6, p475
- ISSN
1529-2908
- Publication type
Journal Article
- DOI
10.1038/82717