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- Title
Cancer predisposition caused by elevated mitotic recombination in Bloom mice.
- Authors
Luo, G; Santoro, I M; McDaniel, L D; Nishijima, I; Mills, M; Youssoufian, H; Vogel, H; Schultz, R A; Bradley, A
- Abstract
Bloom syndrome is a disorder associated with genomic instability that causes affected people to be prone to cancer. Bloom cell lines show increased sister chromatid exchange, yet are proficient in the repair of various DNA lesions. The underlying cause of this disease are mutations in a gene encoding a RECQ DNA helicase. Using embryonic stem cell technology, we have generated viable Bloom mice that are prone to a wide variety of cancers. Cell lines from these mice show elevations in the rates of mitotic recombination. We demonstrate that the increased rate of loss of heterozygosity (LOH) resulting from mitotic recombination in vivo constitutes the underlying mechanism causing tumour susceptibility in these mice.
- Publication
Nature genetics, 2000, Vol 26, Issue 4, p424
- ISSN
1061-4036
- Publication type
Journal Article
- DOI
10.1038/82548