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- Title
Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19<sup>ARF</sup>) and is amplified in a subset of human breast cancers.
- Authors
Jacobs, Jacqueline J.L.; Keblusek, Petra; Robanus-Maandag, Els; Kristel, Petra; Lingbeek, Merel; Nederlof, Petra M.; van Welsem, Tibor; van de Vijver, Marc J.; Koh, Eugene Y.; Daley, George Q.; van Lohuizen, Maarten
- Abstract
To identify new immortalizing genes with potential roles in tumorigenesis, we performed a genetic screen aimed to bypass the rapid and tight senescence arrest of primary fibroblasts deficient for the oncogene Bmi1. We identified the T-box member TBX2 as a potent immortalizing gene that acts by downregulating Cdkn2a (p19ARF). TBX2 represses the Cdkn2a (p19ARF) promoter and attenuates E2F1, Myc or HRAS-mediated induction of Cdkn2a (p19ARF). We found TBX2 to be amplified in a subset of primary human breast cancers, indicating that it might contribute to breast cancer development.
- Publication
Nature Genetics, 2000, Vol 26, Issue 3, p291
- ISSN
1061-4036
- Publication type
Academic Journal
- DOI
10.1038/81583