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- Title
Solution structure of a zinc domain conserved in yeast copper-regulated transcription factors.
- Authors
Turner, R B; Smith, D L; Zawrotny, M E; Summers, M F; Posewitz, M C; Winge, D R
- Abstract
The three dimensional structure of the N-terminal domain (residues 1-42) of the copper-responsive transcription factor Amtl from Candida glabrata has been determined by two-dimensional 1H-correlated nuclear magnetic resonance (NMR) methods. The domain contains an array of zinc-binding residues (Cys-X2-Cys-X8-Cys-X-His) that is conserved among a family of Cu-responsive transcription factors. The structure is unlike those of previously characterized zinc finger motifs, and consists of a three-stranded antiparallel beta-sheet with two short helical segments that project from one end of the beta-sheet. Conserved residues at positions 16, 18 and 19 form a basic patch that may be important for DNA binding.
- Publication
Nature structural biology, 1998, Vol 5, Issue 7, p551
- ISSN
1072-8368
- Publication type
Journal Article
- DOI
10.1038/805