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- Title
Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus.
- Authors
Horikawa, Y; Oda, N; Cox, N J; Li, X; Orho-Melander, M; Hara, M; Hinokio, Y; Lindner, T H; Mashima, H; Schwarz, P E; del Bosque-Plata, L; Horikawa, Y; Oda, Y; Yoshiuchi, I; Colilla, S; Polonsky, K S; Wei, S; Concannon, P; Iwasaki, N; Schulze, J; Baier, L J; Bogardus, C; Groop, L; Boerwinkle, E; Hanis, C L; Bell, G I
- Abstract
Type 2 or non-insulin-dependent diabetes mellitus (NIDDM) is the most common form of diabetes worldwide, affecting approximately 4% of the world's adult population. It is multifactorial in origin with both genetic and environmental factors contributing to its development. A genome-wide screen for type 2 diabetes genes carried out in Mexican Americans localized a susceptibility gene, designated NIDDM1, to chromosome 2. Here we describe the positional cloning of a gene located in the NIDDM1 region that shows association with type 2 diabetes in Mexican Americans and a Northern European population from the Botnia region of Finland. This putative diabetes-susceptibility gene encodes a ubiquitously expressed member of the calpain-like cysteine protease family, calpain-10 (CAPN10). This finding suggests a novel pathway that may contribute to the development of type 2 diabetes.
- Publication
Nature genetics, 2000, Vol 26, Issue 2, p163
- ISSN
1061-4036
- Publication type
Journal Article
- DOI
10.1038/79876