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- Title
APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity.
- Authors
Yu, G; Boone, T; Delaney, J; Hawkins, N; Kelley, M; Ramakrishnan, M; McCabe, S; Qiu, W R; Kornuc, M; Xia, X Z; Guo, J; Stolina, M; Boyle, W J; Sarosi, I; Hsu, H; Senaldi, G; Theill, L E
- Abstract
We report that the tumor neurosis factor homolog APRIL (a proliferation-inducing ligand) stimulates in vitro proliferation of primary B and T cells and increases spleen weight due to accumulation of B cells in vivo. APRIL functions via binding to BCMA (B cell maturation antigen) and TACI (transmembrane activator and CAML-interactor) and competes with TALL-I (also called BLyS or BAFF) for receptor binding. Soluble BCMA and TACI specifically prevent binding of APRIL and block APRIL-stimulated proliferation of primary B cells. BCMA-Fc also inhibits production of antibodies against keyhole limpet hemocyanin and Pneumovax in mice, indicating that APRIL and/or TALL-I signaling via BCMA and/or TACI are required for generation of humoral immunity. Thus, APRIL-TALL-I and BCMA-TACI form a two ligands-two receptors pathway involved in stimulation of B and T cell function.
- Publication
Nature immunology, 2000, Vol 1, Issue 3, p252
- ISSN
1529-2908
- Publication type
Journal Article
- DOI
10.1038/79802