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- Title
Role of Drosophila IKK gamma in a toll-independent antibacterial immune response.
- Authors
Rutschmann, S; Jung, A C; Zhou, R; Silverman, N; Hoffmann, J A; Ferrandon, D
- Abstract
We have generated, by ethylmethane sulfonate mutagenesis, loss-of-function mutants in the Drosophila homolog of the mammalian I-kappa B kinase (IKK) complex component IKK gamma (also called NEMO). Our data show that Drosophila IKK gamma is required for the Relish-dependent immune induction of the genes encoding antibacterial peptides and for resistance to infections by Escherichia coli. However, it is not required for the Toll-DIF-dependent antifungal host defense. The results indicate distinct control mechanisms of the Rel-like transactivators DIF and Relish in the Drosophila innate immune response and show that Drosophila Toll does not signal through a IKK gamma-dependent signaling complex. Thus, in contrast to the vertebrate inflammatory response, IKK gamma is required for the activation of only one immune signaling pathway in Drosophila.
- Publication
Nature immunology, 2000, Vol 1, Issue 4, p342
- ISSN
1529-2908
- Publication type
Journal Article
- DOI
10.1038/79801