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- Title
CD4<sup>+</sup> T cell survival is not directly linked to self-MHC?induced TCR signaling.
- Authors
Dorfman, Jeffrey R.; Štefanová, Irena; Yasutomo, Koji; Germain, Ronald N.
- Abstract
T cell receptor (TCR) signaling triggered by recognition of self-major histocompatibility complex (MHC) ligands has been proposed to maintain the viability of naïve T cells and to provoke their proliferation in T cell?deficient hosts. Consistent with this, the partially phosphorylated state of TCRζ chains in naïve CD4+ and CD8+ T cells in vivo was found to be actively maintained by TCR interactions with specific peptide-containing MHC molecules. TCR ligand-dependent phosphorylation of TCRζ was lost within one day of cell transfer into MHC-deficient hosts, yet the survival of transferred CD4+ lymphocytes was the same in recipients with or without MHC class II expression for one month. Thus, despite clear evidence for TCR signaling in nonactivated naïve T cells, these data argue against the concept that such signaling plays a predominant role in determining lymphocyte lifespan.
- Publication
Nature Immunology, 2000, Vol 1, Issue 4, p329
- ISSN
1529-2908
- Publication type
Academic Journal
- DOI
10.1038/79783