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- Title
Regulation of tyrosine kinase activation and granule release through beta-arrestin by CXCRI.
- Authors
Barlic, J; Andrews, J D; Kelvin, A A; Bosinger, S E; DeVries, M E; Xu, L; Dobransky, T; Feldman, R D; Ferguson, S S; Kelvin, D J
- Abstract
Chemoattractant-stimulated granule release from neutrophils, basophils and eosinophils is critical for the innate immune response against infectious bacteria. Interleukin 8 (IL-8) activation of the chemokine receptor CXCRI was found to stimulate rapid formation of beta-arrestin complexes with Hck or c-Fgr. Formation of beta-arrestin-Hck complexes led to Hck activation and trafficking of the complexes to granule-rich regions. Granulocytes expressing a dominant-negative beta-arrestin-mutant did not release granules or activate tyrosine kinases after IL-8 stimulation. Thus, beta-arrestins regulate chemokine-induced granule exocytosis, indicating a broader role for beta-arrestins in the regulation of cellular functions than was previously suspected.
- Publication
Nature immunology, 2000, Vol 1, Issue 3, p227
- ISSN
1529-2908
- Publication type
Journal Article
- DOI
10.1038/79767