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- Title
Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection.
- Authors
Hazenberg, M D; Otto, S A; Cohen Stuart, J W; Verschuren, M C; Borleffs, J C; Boucher, C A; Coutinho, R A; Lange, J M; Rinke de Wit, T F; Tsegaye, A; van Dongen, J J; Hamann, D; de Boer, R J; Miedema, F
- Abstract
Recent thymic emigrants can be identified by T cell receptor excision circles (TRECs) formed during T-cell receptor rearrangement. Decreasing numbers of TRECs have been observed with aging and in human immunodeficiency virus (HIV)-1 infected individuals, suggesting thymic impairment. Here, we show that in healthy individuals, declining thymic output will affect the TREC content only when accompanied by naive T-cell division. The rapid decline in TRECs observed during HIV-1 infection and the increase following HAART are better explained not by thymic impairment, but by changes in peripheral T-cell division rates. Our data indicate that TREC content in healthy individuals is only indirectly related to thymic output, and in HIV-1 infection is mainly affected by immune activation.
- Publication
Nature medicine, 2000, Vol 6, Issue 9, p1036
- ISSN
1078-8956
- Publication type
Journal Article
- DOI
10.1038/79549