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- Title
Combinatorial chemoprevention of intestinal neoplasia.
- Authors
Torrance, C J; Jackson, P E; Montgomery, E; Kinzler, K W; Vogelstein, B; Wissner, A; Nunes, M; Frost, P; Discafani, C M
- Abstract
A combination of two drugs afforded remarkable protection from intestinal neoplasia in APC(Min/+) mice, a murine model of human familial adenomatous polyposis (FAP). One of the drugs was sulindac, a prototypical non-steroidal anti-inflammatory drug with established chemopreventative activity. The second drug was EKI-569, a newly developed, irreversible inhibitor of the epidermal growth factor receptor kinase. Although 100% of the untreated APC(Min/+) mice developed approximately 20 polyps, nearly half the mice treated with these two agents developed no polyps at all. These results suggest a powerful strategy for the chemoprevention of human colonic neoplasia.
- Publication
Nature medicine, 2000, Vol 6, Issue 9, p1024
- ISSN
1078-8956
- Publication type
Journal Article
- DOI
10.1038/79534