We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Limitin: An interferon-like cytokine that preferentially influences B-lymphocyte precursors.
- Authors
Oritani, K; Medina, K L; Tomiyama, Y; Ishikawa, J; Okajima, Y; Ogawa, M; Yokota, T; Aoyama, K; Takahashi, I; Kincade, P W; Matsuzawa, Y
- Abstract
We have identified an interferon-like cytokine, limitin, on the basis of its ability to arrest the growth of or kill lympho-hematopoietic cells. Limitin strongly inhibited B lymphopoiesis in vitro and in vivo but had little influence on either myelopoiesis or erythropoiesis. Because limitin uses the interferon alpha/beta receptors and induces interferon regulatory factor-1, it may represent a previously unknown type I interferon prototype. However, preferential B-lineage growth inhibition and activation of Janus kinase 2 in a myelomonocytic leukemia line have not been described for previously known interferons.
- Publication
Nature medicine, 2000, Vol 6, Issue 6, p659
- ISSN
1078-8956
- Publication type
Journal Article
- DOI
10.1038/76233