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- Title
Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo.
- Authors
Fernandez, N C; Lozier, A; Flament, C; Ricciardi-Castagnoli, P; Bellet, D; Suter, M; Perricaudet, M; Tursz, T; Maraskovsky, E; Zitvogel, L
- Abstract
Cytotoxic T lymphocytes and natural killer cells are essential effectors of anti-tumor immune responses in vivo. Dendritic cells (DC) 'prime' tumor antigen-specific cytotoxic T lymphocytes; thus, we investigated whether DC might also trigger the innate, NK cell-mediated anti-tumor immunity. In mice with MHC class I-negative tumors, adoptively transferred- or Flt3 ligand-expanded DC promoted NK cell-dependent anti-tumor effects. In vitro studies demonstrated a cell-to-cell contact between DC and resting NK cells that resulted in a substantial increase in both NK cell cytolytic activity and IFN-gamma production. Thus, DC are involved in the interaction between innate and adaptive immune responses.
- Publication
Nature medicine, 1999, Vol 5, Issue 4, p405
- ISSN
1078-8956
- Publication type
Journal Article
- DOI
10.1038/7403