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- Title
Enhancement of synaptic transmission by cyclic AMP modulation of presynaptic I<sub>h</sub> channels.
- Authors
Beaumont, Vahri; Zucker, Robert S.
- Abstract
Presynaptic activation of adenylyl cyclase and subsequent generation of cAMP represent an important mechanism in the modulation of synaptic transmission. In many cases, short- to mediumterm modulation of synaptic strength by cAMP is due to activation of protein kinase A and subsequent covalent modification of presynaptic ion channels or synaptic proteins. Here we show that presynaptic cAMP generation via serotonin receptor activation directly modulated hyperpolarization-activated cation channels (I[sub h] channels) in axons. This modulation of I[sub h] produced an increase in synaptic strength that could not be explained solely by depolarization of the presynaptic membrane. These studies identify a mechanism by which cAMP and I[sub h] regulate synaptic plasticity.
- Publication
Nature Neuroscience, 2000, Vol 3, Issue 2, p133
- ISSN
1097-6256
- Publication type
Academic Journal
- DOI
10.1038/72072