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- Title
δ-Tubulin and ε-tubulin: two new human centrosomal tubulins reveal new aspects of centrosome structure and function.
- Authors
Chang, Paul; Stearns, Tim
- Abstract
The centrosome organizes microtubules, which are made up of α-tubulin and β-tubulin, and contains centrosome- bound γ-tubulin, which is involved in microtubule nucleation. Here we identify two new human tubulins and show that they are associated with the centrosome. One is a homologue of the Chlamydomonas δ-tubulin Uni3, and the other is a new tubulin, which we have named ε-tubulin. Localization of δ-tubulin and ε-tubulin to the centrosome is independent of microtubules, and the patterns of localization are distinct from each other and from that of γ-tubulin. δ-Tubulin is found in association with the centrioles, whereas ε-tubulin localizes to the pericentriolar material. ε-Tubulin exhibits a cell-cycle-specific pattern of localization, first associating with only the older of the centrosomes in a newly duplicated pair and later associating with both centrosomes. ε-Tubulin thus distinguishes the old centrosome from the new at the level of the pericentriolar material, indicating that there may be a centrosomal maturation event that is marked by the recruitment of ε-tubulin.
- Publication
Nature Cell Biology, 2000, Vol 2, Issue 1, p30
- ISSN
1465-7392
- Publication type
Academic Journal
- DOI
10.1038/71350