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- Title
Molecular basis for resistance to silver cations in Salmonella.
- Authors
Gupta, A; Matsui, K; Lo, J F; Silver, S
- Abstract
Here we report the genetic and proposed molecular basis for silver resistance in pathogenic microorganisms. The silver resistance determinant from a hospital burn ward Salmonella plasmid contains nine open reading frames, arranged in three measured and divergently transcribed RNAs. The resistance determinant encodes a periplasmic silver-specific binding protein (SilE) plus apparently two parallel efflux pumps: one, a P-type ATPase (SilP); the other, a membrane potential-dependent three-polypeptide cation/proton antiporter (SilCBA). The sil determinant is governed by a two-component membrane sensor and transcriptional responder comprising silS and silR, which are co-transcribed. The availability of the sil silver-resistance determinant will be the basis for mechanistic molecular and biochemical studies as well as molecular epidemiology of silver resistance in clinical settings in which silver is used as a biocide.
- Publication
Nature medicine, 1999, Vol 5, Issue 2, p183
- ISSN
1078-8956
- Publication type
Journal Article
- DOI
10.1038/5545