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- Title
Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene.
- Authors
Guo-Liang Xu; Bestor, Timothy H.; Bourc'his, Deborah; Chih-Lin Hsieh; Tommerup, Niels; Bugge, Merete; Hulten, Maj; Xiaoyan Qu; Russo, James J.; Viegas-Pequignot, Evani
- Abstract
Reports a study which examines the immunodeficiency syndrome caused by mutation in a DNA methyltransferase gene in patients with the recessive autosomal disorder known as ICF syndrome. Why most ICF patients succumb to infectious diseases before adulthood; Observation that ICF syndrome is the only genetic disorder known to involve abnormalities of genomic methylation patterns; Role of enzymes.
- Publication
Nature, 1999, Vol 402, Issue 6758, p187
- ISSN
0028-0836
- Publication type
Academic Journal
- DOI
10.1038/46052