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- Title
Gene therapy: therapeutic gene causing lymphoma.
- Authors
Woods, Niels-Bjarne; Bottero, Virginie; Schmidt, Manfred; von Kalle, Christof; Verma, Inder M
- Abstract
The development of T-cell leukaemia following the otherwise successful treatment of three patients with X-linked severe combined immune deficiency (X-SCID) in gene-therapy trials using haematopoietic stem cells has led to a re-evaluation of this approach. Using a mouse model for gene therapy of X-SCID, we find that the corrective therapeutic gene IL2RG itself can act as a contributor to the genesis of T-cell lymphomas, with one-third of animals being affected. Gene-therapy trials for X-SCID, which have been based on the assumption that IL2RG is minimally oncogenic, may therefore pose some risk to patients.
- Publication
Nature, 2006, Vol 440, Issue 7088, p1123
- ISSN
1476-4687
- Publication type
Journal Article
- DOI
10.1038/4401123a