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- Title
Avian flu: isolation of drug-resistant H5N1 virus.
- Authors
Le, Q Mai; Kiso, Maki; Someya, Kazuhiko; Sakai, Yuko T; Nguyen, T Hien; Nguyen, Khan H L; Pham, N Dinh; Ngyen, Ha H; Yamada, Shinya; Muramoto, Yukiko; Horimoto, Taisuke; Takada, Ayato; Goto, Hideo; Suzuki, Takashi; Suzuki, Yasuo; Kawaoka, Yoshihiro
- Abstract
The persistence of H5N1 avian influenza viruses in many Asian countries and their ability to cause fatal infections in humans have raised serious concerns about a global flu pandemic. Here we report the isolation of an H5N1 virus from a Vietnamese girl that is resistant to the drug oseltamivir, which is an inhibitor of the viral enzyme neuraminidase and is currently used for protection against and treatment of influenza. Further investigation is necessary to determine the prevalence of oseltamivir-resistant H5N1 viruses among patients treated with this drug.
- Publication
Nature, 2005, Vol 437, Issue 7062, p1108
- ISSN
1476-4687
- Publication type
Journal Article
- DOI
10.1038/4371108a