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- Title
Phytochemistry: ibuprofen-like activity in extra-virgin olive oil.
- Authors
Beauchamp, Gary K; Keast, Russell S J; Morel, Diane; Lin, Jianming; Pika, Jana; Han, Qiang; Lee, Chi-Ho; Smith, Amos B; Breslin, Paul A S
- Abstract
Newly pressed extra-virgin olive oil contains oleocanthal--a compound whose pungency induces a strong stinging sensation in the throat, not unlike that caused by solutions of the non-steroidal anti-inflammatory drug ibuprofen. We show here that this similar perception seems to be an indicator of a shared pharmacological activity, with oleocanthal acting as a natural anti-inflammatory compound that has a potency and profile strikingly similar to that of ibuprofen. Although structurally dissimilar, both these molecules inhibit the same cyclooxygenase enzymes in the prostaglandin-biosynthesis pathway.
- Publication
Nature, 2005, Vol 437, Issue 7055, p45
- ISSN
1476-4687
- Publication type
Journal Article
- DOI
10.1038/437045a