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- Title
Tumour biology: senescence in premalignant tumours.
- Authors
Collado, Manuel; Gil, Jesús; Efeyan, Alejo; Guerra, Carmen; Schuhmacher, Alberto J; Barradas, Marta; Benguría, Alberto; Zaballos, Angel; Flores, Juana M; Barbacid, Mariano; Beach, David; Serrano, Manuel
- Abstract
Oncogene-induced senescence is a cellular response that may be crucial for protection against cancer development, but its investigation has so far been restricted to cultured cells that have been manipulated to overexpress an oncogene. Here we analyse tumours initiated by an endogenous oncogene, ras, and show that senescent cells exist in premalignant tumours but not in malignant ones. Senescence is therefore a defining feature of premalignant tumours that could prove valuable in the diagnosis and prognosis of cancer.
- Publication
Nature, 2005, Vol 436, Issue 7051, p642
- ISSN
1476-4687
- Publication type
Journal Article
- DOI
10.1038/436642a