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- Title
Medical genetics: a marker for Stevens-Johnson syndrome.
- Authors
Chung, Wen-Hung; Hung, Shuen-Iu; Hong, Hong-Shang; Hsih, Mo-Song; Yang, Li-Cheng; Ho, Hsin-Chun; Wu, Jer-Yuarn; Chen, Yuan-Tsong
- Abstract
Stevens-Johnson syndrome and the related disease toxic epidermal necrolysis are life-threatening reactions of the skin to particular types of medication. Here we show that there is a strong association in Han Chinese between a genetic marker, the human leukocyte antigen HLA-B*1502, and Stevens-Johnson syndrome induced by carbamazepine, a drug commonly prescribed for the treatment of seizures. It should be possible to exploit this association in a highly reliable test to predict severe adverse reaction, as well as for investigation of the pathogenesis of Stevens-Johnson syndrome.
- Publication
Nature, 2004, Vol 428, Issue 6982, p486
- ISSN
1476-4687
- Publication type
Journal Article
- DOI
10.1038/428486a