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- Title
The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function.
- Authors
Torchia, J; Rose, D W; Inostroza, J; Kamei, Y; Westin, S; Glass, C K; Rosenfeld, M G
- Abstract
The functionally conserved proteins CBP and p300 act in conjunction with other factors to activate transcription of DNA. A new factor, p/CIP, has been discovered that is present in the cell as a complex with CBP and is required for transcriptional activity of nuclear receptors and other CBP/p300-dependent transcription factors. The highly related nuclear-receptor co-activator protein NCoA-1 is also specifically required for ligand-dependent activation of genes by nuclear receptors. p/CIP, NCoA-1 and CBP all contain related leucine-rich charged helical interaction motifs that are required for receptor-specific mechanisms of gene activation, and allow the selective inhibition of distinct signal-transduction pathways.
- Publication
Nature, 1997, Vol 387, Issue 6634, p677
- ISSN
0028-0836
- Publication type
Journal Article
- DOI
10.1038/42652