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- Title
Amyloid pores from pathogenic mutations.
- Authors
Lashuel, Hilal A.; Hartley, Dean; Petre, Benjamin M.; Walz, Thomas; Lansbury Jr, Peter T.
- Abstract
Discusses a study which investigated that mutant amyloid proteins associated with Alzheimer's and Parkinson's diseases form morphologically indistinguishable annular protofibrils. Mechanism which increases the possibility that a molecular species other than the amyloid fibril could be pathogenic; Observations which suggest that a protofibril can be detoxified by conversion to a fibril; Discussion on the toxicity of protofibrils.
- Publication
Nature, 2002, Vol 418, Issue 6895, p291
- ISSN
0028-0836
- Publication type
Academic Journal
- DOI
10.1038/418291a