We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
RNA interference in adult mice.
- Authors
McCaffrey, Anton P; Meuse, Leonard; Pham, Thu-Thao T; Conklin, Douglas S; Hannon, Gregory J; Kay, Mark A
- Abstract
RNA interference is an evolutionarily conserved surveillance mechanism that responds to double-stranded RNA by sequence-specific silencing of homologous genes. Here we show that transgene expression can be suppressed in adult mice by synthetic small interfering RNAs and by small-hairpin RNAs transcribed in vivo from DNA templates. We also show the therapeutic potential of this technique by demonstrating effective targeting of a sequence from hepatitis C virus by RNA interference in vivo.
- Publication
Nature, 2002, Vol 418, Issue 6893, p38
- ISSN
0028-0836
- Publication type
Journal Article
- DOI
10.1038/418038a