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- Title
An extensive network of coupling among gene expression machines.
- Authors
Maniatis, Tom; Reed, Robin
- Abstract
Gene expression in eukaryotes requires several multi-component cellular machines. Each machine carries out a separate step in the gene expression pathway, which includes transcription, several pre-messenger RNA processing steps and the export of mature mRNA to the cytoplasm. Recent studies lead to the view that, in contrast to a simple linear assembly line, a complex and extensively coupled network has evolved to coordinate the activities of the gene expression machines. The extensive coupling is consistent with a model in which the machines are tethered to each other to form 'gene expression factories' that maximize the efficiency and specificity of each step in gene expression.
- Publication
Nature, 2002, Vol 416, Issue 6880, p499
- ISSN
0028-0836
- Publication type
Journal Article
- DOI
10.1038/416499a