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- Title
Genome shuffling leads to rapid phenotypic improvement in bacteria.
- Authors
Ying-Xin Zhang; Perry, Kim; Vinci, Victor A.; Powell, Keith; Stemmer, Willem P.C.; del Cardayré, Stephen B.
- Abstract
Demonstrates the process of genome shuffling leading to rapid phenotypic improvement in bacteria through tylosin production from Streptomyces fradiae. Evidence showing that recursive genomic recombination within a population of bacteria can efficiently generate combinatorial libraries of new strains; Ability of the approach to facilitate cell and metabolic engineering.
- Publication
Nature, 2002, Vol 415, Issue 6872, p644
- ISSN
0028-0836
- Publication type
Academic Journal
- DOI
10.1038/415644a