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- Title
Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE.
- Authors
Ye, Keqiang; Aghdasi, Bahman; Luo, Hongbo R; Moriarity, John L; Wu, Frederick Y; Hong, Jenny J; Hurt, K Joseph; Bae, Sun Sik; Suh, Pann-Ghill; Snyder, Solomon H
- Abstract
Phospholipase C gamma 1 (PLC-gamma 1) hydrolyses phosphatidylinositol-4,5-bisphosphate to the second messengers inositol-1,4,5-trisphosphate and diacylglycerol. PLC-gamma 1 also has mitogenic activity upon growth-factor-dependent tyrosine phosphorylation; however, this activity is not dependent on the phospholipase activity of PLC-gamma 1, but requires an SH3 domain. Here, we demonstrate that PLC-gamma 1 acts as a guanine nucleotide exchange factor (GEF) for PIKE (phosphatidylinositol-3-OH kinase (PI(3)K) enhancer). PIKE is a nuclear GTPase that activates nuclear PI(3)K activity, and mediates the physiological activation by nerve growth factor (NGF) of nuclear PI(3)K activity. This enzymatic activity accounts for the mitogenic properties of PLC-gamma 1.
- Publication
Nature, 2002, Vol 415, Issue 6871, p541
- ISSN
0028-0836
- Publication type
Journal Article
- DOI
10.1038/415541a