We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Functional neurogenesis in the adult hippocampus.
- Authors
van Praag, Henriette; Schinder, Alejandro F; Christie, Brian R; Toni, Nicolas; Palmer, Theo D; Gage, Fred H
- Abstract
There is extensive evidence indicating that new neurons are generated in the dentate gyrus of the adult mammalian hippocampus, a region of the brain that is important for learning and memory. However, it is not known whether these new neurons become functional, as the methods used to study adult neurogenesis are limited to fixed tissue. We use here a retroviral vector expressing green fluorescent protein that only labels dividing cells, and that can be visualized in live hippocampal slices. We report that newly generated cells in the adult mouse hippocampus have neuronal morphology and can display passive membrane properties, action potentials and functional synaptic inputs similar to those found in mature dentate granule cells. Our findings demonstrate that newly generated cells mature into functional neurons in the adult mammalian brain.
- Publication
Nature, 2002, Vol 415, Issue 6875, p1030
- ISSN
0028-0836
- Publication type
Journal Article
- DOI
10.1038/4151030a