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- Title
A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB.
- Authors
DiDonato, J A; Hayakawa, M; Rothwarf, D M; Zandi, E; Karin, M
- Abstract
Nuclear transcription factors of the NF-kappaB/Rel family are inhibited by IkappaB proteins, which inactivate NF-kappaB by trapping it in the cell cytoplasm. Phosphorylation of IkappaBs marks them out for destruction, thereby relieving their inhibitory effect on NF-kappaB. A cytokine-activated protein kinase complex, IKK (for IkappaB kinase), has now been purified that phosphorylates IkappaBs on the sites that trigger their degradation. A component of IKK was molecularly cloned and identified as a serine kinase. IKK turns out to be the long-sought-after protein kinase that mediates the critical regulatory step in NF-kappaB activation.
- Publication
Nature, 1997, Vol 388, Issue 6642, p548
- ISSN
0028-0836
- Publication type
Journal Article
- DOI
10.1038/41493